![]() ![]() The team then exposed the mice to the SARS-CoV-2 spike protein, the main protein targeted by our antibodies and current vaccines, from the original Wuhan-Hu-1 coronavirus strain. ![]() This pushed the mice’s immune cells to quickly produce a diverse repertoire of antibodies resembling those our bodies might make. The researchers first inserted two human gene segments into the mice. The modified model mimics - and refines - the trial-and-error process our own immune systems use to create increasingly effective antibodies when we encounter an invader. These mice essentially have built-in human immune systems. Led by Alt and Sai Luo, HMS instructor in pediatrics at Boston Children’s, the team first modified a mouse model the Alt lab created to search for broadly neutralizing antibodies to HIV, another virus that frequently mutates. “If it does,” he added, “it might provide a new therapeutic and also contribute to new vaccine strategies.”įindings were published in Science Immunology on Aug. Janeway Professor of Pediatrics at Boston Children’s, professor of genetics at HMS, and a senior investigator on the study. “We hope this antibody will prove to be as effective in patients as it has been in preclinical evaluations thus far,” said Frederick Alt, the HMS Charles A. In lab tests, it neutralized all currently known SARS-CoV-2 variants of concern, including all omicron variants. Harvard COVID-19 Information: Keep Harvard HealthyĪn antibody developed by researchers at Harvard Medical School and Boston Children’s Hospital now seems to fit the bill.Research Departments, Centers, Initiatives and more. ![]()
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